Jak&ndash;STAT regulation of male germline stem cell establishment during Drosophila embryogenesis

X. Rebecca Sheng; Trevor Posenau; Juliann J. Gumulak-Smith; Erika Matunis; Mark Van Doren; Matthew Wawersik

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Jak–STAT regulation of male germline stem cell establishment during Drosophila embryogenesis

机译：果蝇胚胎发生过程中雄性种系干细胞建立的Jak STAT调控

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Germlinestemcells(GSCs)inemDrosophila/emaredescendantsofprimordialgermcells(PGCs)specifiedduringembryogenesis.TheprecisetimingofGSCestablishmentinthetestishasnotbeendetermined,norisitknownwhethermechanismsthatcontrolGSCmaintenanceintheadultareinvolvedinGSCestablishment.Here,wedeterminethatPGCsinthedevelopingmalegonadfirstbecomeGSCsattheembryotolarvaltransition.Thiscoincideswithformationoftheembryonichub;thecriticalsignalingcenterthatregulatesadultGSCbehaviorwithinthestemcellmicroenvironment(niche).WefindthattheJakndash;STATsignalingpathwayisactivatedinasubsetofPGCsthatassociatewiththenewly-formedembryonichub.ThesePGCsexpressGSCmarkersandfunctionlikeGSCs,whilePGCsthatdonotassociatewiththehubbegintodifferentiate.IntheabsenceofJakndash;STATactivation,PGCsadjacenttothehubfailtoexhibitthecharacteristicsofGSCs,whileectopicactivationoftheJakndash;STATpathwaypreventsdifferentiation.Thesefindingsshowthatstemcellformationiscloselylinkedtodevelopmentofthestemcellniche,andsuggestthatJakndash;STATsignalingisrequiredforinitialestablishmentoftheGSCpopulationindevelopingtestes./p/div

机译：Germlinestemcells（GSC中）中的果蝇 aredescendantsofprimordialgermcells（的PGC）specifiedduringembryogenesis.TheprecisetimingofGSCestablishmentinthetestishasnotbeendetermined，norisitknownwhethermechanismsthatcontrolGSCmaintenanceintheadultareinvolvedinGSCestablishment.Here，wedeterminethatPGCsinthedevelopingmalegonadfirstbecomeGSCsattheembryotolarvaltransition.Thiscoincideswithformationoftheembryonichub; thecriticalsignalingcenterthatregulatesadultGSCbehaviorwithinthestemcellmicroenvironment（优势）.WefindthattheJakndash; STATsignalingpathwayisactivatedinasubsetofPGCsthatassociatewiththenewly-formedembryonichub.ThesePGCsexpressGSCmarkersandfunctionlikeGSCs，whilePGCsthatdonotassociatewiththehubbegintodifferentiate.IntheabsenceofJakndash; STATactivation，PGCsadjacenttothehubfailtoexhibitthecharacteristicsofGSCs，这些发现表明，干细胞的形成与干细胞的发展密切相关，并建议干细胞的发展。最初需要建立TAT信号来建立开发中的GSC种群。 展开▼

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《Developmental biology》 |2009年第2期|共页

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X. Rebecca Sheng; Trevor Posenau; Juliann J. Gumulak-Smith; Erika Matunis; Mark Van Doren; Matthew Wawersik;
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中图分类生物科学;

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1. Jak-STAT regulation of male germline stem cell establishment during Drosophila embryogenesis. [J] . Sheng XR, Posenau T, Gumulak Smith JJ Developmental biology . 2009,第2期

机译：果蝇胚胎发生过程中雄性种系干细胞建立的Jak-STAT调节。

2. Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster [J] . Zixing Wang, Jae H. Park, Chun-Hong Chen, Biology Open . 2013,第3期

机译：严峻的程序性细胞死亡在果蝇胚胎发生和变态过程中建立corazonin产生的肽能神经系统中的重要作用严峻的程序性细胞死亡在果蝇的胚胎发生和变形过程中建立corazonin产生的肽能神经系统中的重要作用。果蝇致死的程序性细胞死亡在果蝇胚胎发生和变态过程中建立可乐宁生产肽能神经系统的建立中的重要作用

3. Niche signaling promotes stem cell survival in the Drosophila testis via the JAK–STAT target DIAP1 [J] . Salman Hasan, Phylis Heacute, tieacute, Developmental biology . 2015,第1期

机译：生态位信号通过JAKSTAT靶点DIAP1促进果蝇睾丸中的干细胞存活。

4. Regulation of Self-renewal and Differentiation in Adult StemCell Lineages: Lessons from the Drosophila Male Germ Line [C] . E.L. DAVIES, M.T. FULLER Cold Harbor Symposium on Quantitative Biology . 2008

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5. Regulation of germline stem cells in Drosophila through intrinsic and extrinsic factors: Insulin signaling, microRNA dependent regulation of Cyclin dependent kinase, and the TGF-beta pathway. [D] . Reynolds, Steven H. 2010

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6. Jak-STAT regulation of male germline stem cell establishment during Drosophila embryogenesis [O] . X. Rebecca Sheng, Trevor Posenau, Juliann J. Gumulak-Smith, -1

机译：果蝇胚胎发生过程中雄性种系干细胞的jak-stat调节

7. Jak–STAT regulation of male germline stem cell establishment during Drosophila embryogenesis [O] . Sheng X. Rebecca, Posenau Trevor, Gumulak-Smith Juliann J., 2009

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6. 雷帕霉素调控衰老果蝇中肠干细胞增殖延缓衰老 [C] . 樊晓兰 ,吴奇 ,杨明耀 . 第五届中国衰老与抗衰老学术大会暨第四届全国老年基础与转化医学论坛 . 2015

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Jak&ndash;STAT regulation of male germline stem cell establishment during Drosophila embryogenesis

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Jak–STAT regulation of male germline stem cell establishment during Drosophila embryogenesis