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Growth regulation of the interstitial cell population in hydra: III. Interstitial cell density does not control stem cell proliferation☆

机译:水中间质细胞群的生长调节:III。间质细胞密度不能控制干细胞增殖☆

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Theinterstitialcellsofhydracontainastemcellpopulationwhichproducesseveralclassesofdifferentiatedcelltypes.Amodelhasbeenproposedwhichgovernsthegrowthrateoftheinterstitialcellpopulation.Thismodel,basedonthedensityofinterstitialcellsinthetissue,makesspecificpredictionsabouttherelationshipsamongthisdensity,theproportionofstemcellsintheinterstitialcellpopulation,thegrowthrateoftheinterstitialcellpopulation,andtheamountofnematocytedifferentiation.Hydroxyureatreatmentswereusedtoexperimentallyreduceinterstitialcellnumbers,andthevalidityoftheseexpectedcorrelationswastested.Theresultsdemonstratethatthepredictionsoftheinterstitialcelldensitymodelwerenotupheld.Furthermore,thefindingssuggestthattheinterstitialcellsareaheterogeneouspopulation,containingsomecellswhicharenolongerstemcellsbutwhichdoretainalimitedcapacityforproliferation.Inthefollowingpaper(S.HeimfeldandH.R.Bode,1986,Dev.Biol.115,59a€“68)wehaveproposedanalternativemechanismtoexplaintheobservedcorrelations,whichincorporatesthisheterogeneityintoamplificationdivisionsofinterstitialcellsalreadycommittedtodifferentiation.
机译:Theinterstitialcellsofhydracontainastemcellpopulationwhichproducesseveralclassesofdifferentiatedcelltypes.Amodelhasbeenproposedwhichgovernsthegrowthrateoftheinterstitialcellpopulation.Thismodel,basedonthedensityofinterstitialcellsinthetissue,makesspecificpredictionsabouttherelationshipsamongthisdensity,theproportionofstemcellsintheinterstitialcellpopulation,thegrowthrateoftheinterstitialcellpopulation,andtheamountofnematocytedifferentiation.Hydroxyureatreatmentswereusedtoexperimentallyreduceinterstitialcellnumbers,andthevalidityoftheseexpectedcorrelationswastested.Theresultsdemonstratethatthepredictionsoftheinterstitialcelldensitymodelwerenotupheld.Furthermore,thefindingssuggestthattheinterstitialcellsareaheterogeneouspopulation,containingsomecellswhicharenolongerstemcellsbutwhichdoretainalimitedcapacityforproliferation.Inthefollowingpaper(S.HeimfeldandH.R.Bode,1986年,Dev.Biol.115,59a€“68 )我们提出了一种替代机制来解释所观察到的相关因素,其中包括已经将间质细胞的不完整性划分划分为分化。

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