Response to “Effective” Plasma Renin Activity: A Derived Measure for Assessing Residual Plasma Renin Activity in Patients Taking Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers

摘要

We thank Sealey et al1 for their interest in our article and their comments. They point out that plasma renin activity (PRA) in our study likely overestimated the true activity of circulating PRA and, by calculating the effective PRA, our results would be predictable. Suppressed PRA is a marker of volume overload and can occur with high dietary salt ingestion. Theoretically, patients with suppressed PRA might achieve greater blood pressure (BP) reductions with a low-salt diet than patients with high PRA because of greater salt sensitivity.Some …