首页> 外文期刊>The Journal of Experomental Medicine >Gene conversion variations generate structurally distinct pilin polypeptides in Neisseria gonorrhoeae.
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Gene conversion variations generate structurally distinct pilin polypeptides in Neisseria gonorrhoeae.

机译:基因转化变异在淋病奈瑟氏球菌中产生结构上不同的菌毛蛋白多肽。

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Pilus+ to pilus- phenotype change occurs in Neisseria gonorrhoeae through gene conversion of the gonococcus' complete, expressed pilin gene by nucleotides homologous to the pilS1 copy 5 partial pilin gene; assembly missense pilin is synthesized but pili are not. Reversion to pilus+ occurs by a subsequent recombinational event that replaces the complete pilin gene's pilS1 copy 5-like sequence with nucleotides from a different partial gene to effect expression of an orthodox (i.e., pilus producing) pilin. Sibling pilus+ revertants of common parentage can carry different sequences in their expressed pilin genes because they have undergone nonidentical gene conversion events such as recombinations with sequences from different partial genes, or recombinations with different length nucleotide stretches of the same partial gene; either can yield structurally and antigenically variant pilin polypeptides.
机译:淋病奈瑟菌中的Pilus +到菌毛-表型发生变化,这是由于淋球菌的完整,表达的菌毛蛋白基因通过与pilS1复制5部分菌毛蛋白基因同源的核苷酸而发生的。组装Missense pilin是合成的,而pili不是。向菌毛+的转化是由随后的重组事件发生的,该事件用来自不同部分基因的核苷酸替换完整的菌毛蛋白基因的pilS1拷贝5样序列,从而影响正统(即产生菌毛)菌毛蛋白的表达。同胞的同胞菌毛+回复子在表达的菌毛蛋白基因中可以携带不同的序列,因为它们经历了不相同的基因转换事件,例如与来自不同部分基因的序列重组,或与同一部分基因的不同长度核苷酸延伸的重组;两者均可产生结构和抗原变异的菌毛蛋白多肽。

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