Bar Mitzvah for B-1 Cells: How Will They Grow Up?

摘要

The discovery of CD5+ B cells by Hayakawa et al. (([1][1])) initiated a 13 year-long discussion about the origin and functional properties of these cells. The CD5+ B cells (B-1a) and their phenotypic CD5? “twins” (B-1b cells) differ from conventional peripheral B cells (B-2) by anatomical