Cisplatin Induced Hyponatremic Seizures Secondary to SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion): A Rare Presentation.

摘要

ABSTRACT We report a case of a patient aged 65 years' who presented with histopathological proven metastatic squamous cell cancer of the anal canal . After the necessary workup she was planned for Cisplatin and Fluoropyrimidine based palliative chemotherapy. On day 4 following chemotherapy the patient developed an episode of Generalized Tonic Clonic Seizures, which on further evaluation was attributed to hyponatremia as a result of SIADH secondary to Cisplatin. She required ICU care but made a c.