Cyclic enol ether frameworks, especially stereochemically pure furanoid and pyranoid glycals are well known highly functionalized chiral building blocks. Furanoid glycals have been shown to possess great potential, as they have been used as key intermediates for the synthesis of structurally diverse molecules including natural products with various biological activities since their discovery in 1963 by Ness and Fletcher. In this review on furanoid glycals, efforts are made to exhaustively compile the work centered on synthesis and utility of furanoid glycals since the inception to date. This review aims to highlight the importance of furanoid glycals and the strategies developed over the years for their synthesis. Attention has also been focused on the use of these furanoid glycals toward the synthesis of natural and unnatural products including C-and N-nucleosides of biological importance. Apart from that, efforts are also devoted to cover the significant applications of these furanoid glycals for stereoselective synthesis of various cyclic and acyclic key intermediates of significant interest.
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机译：环状烯醇醚骨架，特别是立体化学上纯的呋喃类和吡喃类糖是众所周知的高度官能化的手性构件。自从Ness和Fletcher于1963年发现呋喃糖以来，它们一直被用作合成结构多样的分子（包括具有多种生物活性的天然产物）的关键中间体，因此具有巨大的潜力。在对呋喃糖的综述中，自从成立以来，人们一直在努力详尽地汇编以呋喃糖的合成和应用为中心的工作。这篇综述旨在强调呋喃糖的重要性以及多年来合成呋喃糖的策略。人们还把注意力集中在使用这些呋喃类化合物的糖类合成天然和非天然产物上，包括具有生物学重要性的 C -和 N -核苷。除此之外，还致力于覆盖这些呋喃类化合物聚糖在立体选择合成各种重要的环状和非环状关键中间体方面的重要应用。
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