Design, Synthesis and Evaluation of Novel Benzoxazole, Benzimidazole and Benzthiazole Based Cationic Lipids as Anticancer agents.

摘要

ABSTRACT Herein, we report on the design, synthesis and cytotoxicities of a series of novel benzoxazole, benzimidazole and benzthiazole based cationic lipids (1a-12b) in breast and lung cancer cell lines. The in vitro cytotoxicities of these lipids were evaluated using MTT assay. The results of the present structure-activity investigation convincingly demonstrate that the benzthiazole based lipids with protonated ammonium group in its headgroup region and C14 hydrocarbon chain as anchoring grou.