Evaluation of Nonsynonymous Single Nucleotide Polymorphisms in the DNMT1 GeneAssociated With Gastric Cancer by an In- Silico Approach.

摘要

ABSTRACT The human DNMT1 (NCBI GENE ID: 1786) gene encodes a DNA methyltransferase-1 which is also termed as maintenance methyltranferase. The DNMT1 (DNA Methyl Tranferase-1) gene plays a substantial role in aberrant DNA methylation in carcinogenesis. Over-expression (Increased activity) and polymorphisms within the DNMT1 gene is allied with a multiplied risk of gastric cancer. Most deleterious non synonymous single nucleotide polymorphisms in the coding region of the DNMT1 gene were investigat.