Decreased GLT‐1 and increased SOD1 and HO‐1 expression in astrocytes contribute to lumbar spinal cord vulnerability of SOD1‐G93A transgenic mice

摘要

TheSOD1‐G93AtransgenicmouseisawidelyusedALSmodel,butthedeathoflowermotorneuronsisthehallmark.Here,weshowthattheSOD1‐G93AtransgeneandHO‐1arepreferentiallyover‐expressedinthelumbarspinalcord,particularlyintheactivatedastrocytesofthetransgenicmice.Wealsoshowdown‐regulationofGLT‐1inspiteoftheproliferatingastrocytes.However,GLT‐1,SOD1‐G93AtransgeneandHO‐1expressionwerenotobviouslychangedinthemotorcortex.OurdatalinkspinalcordvulnerabilitytorelativelydecreasedexpressionofGLT‐1,andhighexpressionofthetransgeneandHO‐1inastrocytesinSOD1‐G93Atransgenicmice...