UV - Spectrophotometric Estimation of Amlodipine Besylate by Using Hydrotropic Solubilization with 1 M Sodium Acetate.

摘要

ABSTRACT Various organic solvents have been employed for the solubilization of poorly water soluble drugs to carry out spectrophotometric analysis. Drawbacks of organic solvents include their high cost, toxicity and pollution. Hydrotropy is a solubilization phenomenon of increasing the solubility of a solute by the addition of high concentrations of alkali metal salts of various organic acids such as sodium benzoate, sodium salicylate, urea, nicotinamide, sodium citrate and sodium acetate and h.