Solid- Lipid Nanoparticles: A Newer Approach for Formulation and Optmization of HMG-CoA Reductase Inhibitors

摘要

ABSTRACT The purpose of the study was to formulate the capsules loaded with the Simvastatin solid lipid nanoparticles using the self emulsifying agent, glyceryl monostearate as the source of lipid for incorporation of Simvastatin to form nanoparticles. Development of solid lipid nanoparticles of Simvastatin and to optimize it for independent variables so as to achieve desired particle size with maximum percent entrapment efficiency and percent cumulative drug release. To achieve the goal and fo.