Characterisation of metronidazole granules prepared by melt granulation and melt dispersion techniques.

摘要

ABSTRACT To investigate the sustained release profile of Metronidazole granules prepared by melt granulation and melt dispersion techniques. Metronidazole granules have been formed by melt granulation whereby the drug powder was triturated in a melted carnuba wax followed by screening, and by melt dispersion whereby the drug and the wax were melted together and the molten mass dispersed in water, allowed to solidly by cooling, dried and then screened. Conventional granules of the drug were also.