Meta‐analyses of human gut microbes associated with obesity and IBD

摘要

Recentstudieshavelinkedhumangutmicrobestoobesityandinflammatoryboweldisease,butconsistentsignalshavebeendifficulttoidentify.HerewetestforindicatortaxaandgeneralfeaturesofthemicrobiotathataregenerallyconsistentacrossstudiesofobesityandofIBD,focusingonstudiesinvolvinghigh‐throughputsequencingofthe16SrRNAgene(whichwecouldprocessusingacommoncomputationalpipeline).WefindthatIBDhasaconsistentsignatureacrossstudiesandallowshighclassificationaccuracyofIBDfromnon‐IBDsubjects,butthatalthoughsubjectscanbeclassifiedasleanorobesewithineachindividualstudywithstatisticallysignificantaccuracy,consistentwiththeabilityofthemicrobiotatoexperimentallytransferthisphenotype,signaturesofobesityarenotconsistentbetweenstudiesevenwhenthedataareanalyzedwithconsistentmethods.Theresultssuggestthatcorrelationsbetweenmicrobesandclinicalconditionswithdifferenteffectsizes(e.g.thelargeeffectsizeofIBDversusthesmalleffectsizeofobesity)mayrequiredifferentcohortselectionandanalysisstrategies...