Low‐intensity pulsed ultrasound‐induced ATP increases bone formation via the P2X7 receptor in osteoblast‐like MC3T3‐E1 cells

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Low‐intensity pulsed ultrasound‐induced ATP increases bone formation via the P2X7 receptor in osteoblast‐like MC3T3‐E1 cells

机译：低强度脉冲超声诱导的ATP通过成骨细胞样MC3T3-E1细胞中的P2X7受体增加骨形成

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Low‐intensitypulsedultrasound(LIPUS)isusedforbonehealinginorthopedicsanddentistry.IthasbeenshownthatLIPUSinducesthesecretionofextracellularadenosinetriphosphate(ATP),akeymediatorofosteoblastresponsetomechanicalstimuli.However,thedetailedmechanismofLIPUS‐inducedosteogenesishasbeenelusive.Inthisstudy,weinvestigatedtheroleoftheP2X7receptorinLIPUS‐inducedosteogenesis.LIPUSinducedthereleaseofextracellularATP,differentiationofosteoblastsandosteogenesisviatheP2X7receptor,withoutaffectingtheactivityofalkalinephosphatase(ALPase).TheseresultssuggestthatLIPUS‐inducedextracellularATPpromotesboneformationviatheosteoblastP2X7receptorindependentlyofALPase...

机译：低intensitypulsedultrasound（LIPUS）isusedforbonehealinginorthopedicsanddentistry.IthasbeenshownthatLIPUSinducesthesecretionofextracellularadenosinetriphosphate（ATP），akeymediatorofosteoblastresponsetomechanicalstimuli.However，thedetailedmechanismofLIPUS-inducedosteogenesishasbeenelusive.Inthisstudy，weinvestigatedtheroleoftheP2X7receptorinLIPUS-inducedosteogenesis.LIPUSinducedthereleaseofextracellularATP，differentiationofosteoblastsandosteogenesisviatheP2X7receptor，withoutaffectingtheactivityofalkalinephosphatase（碱性磷酸酶）.TheseresultssuggestthatLIPUS-inducedextracellularATPpromotesboneformationviatheosteoblastP2X7receptorindependentlyofALPase ...

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《FEBS Letters》 |2014年第3期|共9页
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1. Low-intensity pulsed ultrasound-induced ATP increases bone formation via the P2X7 receptor in osteoblast-like MC3T3-E1 cells [J] . Manaka Soichiro, Tanabe Natsuko, Kariya Taro, FEBS letters. . 2015,第3期

机译：低强度脉冲超声诱导的ATP通过成骨细胞样MC3T3-E1细胞中的P2X7受体增加骨形成
2. Translocation of Akt/PKB to the nucleus of osteoblast‐like MC3T3‐E1 cells exposed to proliferative growth factors [J] . Bellacosa Alfonso, Borgatti Paola, Capitani Silvano, FEBS Letters . 2000,第1a2期

机译：Akt / PKB向暴露于增生性生长因子的成骨样MC3T3-E1细胞核易位
3. Bone morphogenetic proteins (BMP‐2 and BMP‐3) induce the late phase expression of the proto‐oncogene c‐fos in murine osteoblastic MC3T3‐E1 cells [J] . Bentz Hanne, Hiraki Yuji, Ikeda Toshihiko, FEBS Letters . 1992,第3期

机译：骨形态发生蛋白（BMP-2和BMP-3）诱导鼠成骨细胞MC3T3-E1细胞中原癌基因c-fos的晚期表达
4. Increase of intracellular Ca~2+ level induces osteoclast-like cell formation in coculture of mouse bone marrow cells and osteoblastic cells [C] . Masamichi Takami, Je-Tae Woo, Kazuo Nagai Annual Meeting of the Japanese Association for Animal Cell Technology . 1998

机译：细胞内Ca〜2 +水平的增加诱导小鼠骨髓细胞和成骨细胞的共络合中的骨细胞样细胞形成
5. Effects of combined treatment with recombinant human bone morphogenetic protein-2 and low-intensity pulsed ultrasound on bone formation. [D] . Wijdicks, Coen Abel. 2007

机译：重组人骨形态发生蛋白2和低强度脉冲超声联合治疗对骨形成的影响。
6. Basal Activation of the P2X7 ATP Receptor Elevates Mitochondrial Calcium and Potential Increases Cellular ATP Levels and Promotes Serum-independent Growth [O] . Elena Adinolfi, Maria Giulia Callegari, Davide Ferrari, 2005

机译：P2X7 ATP受体的基础激活提高线粒体钙和潜力增加细胞ATP水平并促进血清非依赖性生长。
7. Low-intensity pulsed ultrasound-induced ATP increases bone formation via the P2X7 receptor in osteoblast-like MC3T3-E1 cells [O] . Manaka Soichiro, Tanabe Natsuko, Kariya Taro, 2015

机译：低强度脉冲超声诱导的ATP通过成骨细胞样MC3T3-E1细胞中的P2X7受体增加骨形成

Low‐intensity pulsed ultrasound‐induced ATP increases bone formation via the P2X7 receptor in osteoblast‐like MC3T3‐E1 cells

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