The chemical chaperones tauroursodeoxycholic and 4‐phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

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The chemical chaperones tauroursodeoxycholic and 4‐phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

机译：化学伴侣牛磺去氧胆酸和4-苯基丁酸可加速甲状腺激素的活化和能量消耗

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Exposureofcelllinesendogenouslyexpressingthethyroidhormoneactivatingenzymetype2deiodinase(D2)tothechemicalchaperonestauroursodeoxycholicacid(TUDCA)or4‐phenylbutiricacid(4‐PBA)increasesD2expression,activityandT3production.Inbrownadipocytes,TUDCAor4‐PBAinducedT3‐dependentgenesandoxygenconsumption(～2‐fold),aneffectpartiallylostinD2knockoutcells.Inwildtype,butnotinD2knockoutmice,administrationofTUDCAloweredtherespiratoryquotient,doubledbrownadiposetissueD2activityandnormalizedtheglucoseintoleranceassociatedwithhighfatfeeding.Thus,D2playsacriticalroleinthemetaboliceffectsofchemicalchaperones...

机译：Exposureofcelllinesendogenouslyexpressingthethyroidhormoneactivatingenzymetype2deiodinase（D2）tothechemicalchaperonestauroursodeoxycholicacid（TUDCA）OR 4-phenylbutiricacid（4-PBA）increasesD2expression，activityandT3production.Inbrownadipocytes，TUDCAor4-PBAinducedT3-dependentgenesandoxygenconsumption（〜2倍），aneffectpartiallylostinD2knockoutcells.Inwildtype，butnotinD2knockoutmice，administrationofTUDCAloweredtherespiratoryquotient，doubledbrownadiposetissueD2activityandnormalizedtheglucoseintoleranceassociatedwithhighfatfeeding.Thus，D2playsacriticalroleinthemetaboliceffectsofchemicalchaperones ...

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《FEBS Letters 》 |2011年第3期| 共6页
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1. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. [J] . da Silva WS, Ribich S, Arrojo e Drigo R, FEBS letters. . 2011 ,第3a4期

机译：化学伴侣牛磺去氧胆酸和4-苯基丁酸可加速甲状腺激素的活化和能量消耗。
2. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. [J] . da Silva WS, Ribich S, Arrojo e Drigo R, FEBS letters. . 2011 ,第3a4期

机译：化学伴侣Taurosodoxycholic和4-苯基丁酸加速甲状腺激素活化和能量消耗。
3. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. [J] . da Silva WS, Ribich S, Arrojo e Drigo R, FEBS letters. . 2011 ,第3a4期

机译：化学伴侣Taurosodoxycholic和4-苯基丁酸加速甲状腺激素活化和能量消耗。
4. Mercury, omega-3 fatty acids, thyroid hormones, and thyroid antibodies in an adult cohort of avid seafood consumers [C] . Jaymie Meliker, Roxanne Karimi, Susan Silbernagel, Annual conference of the International Society of Exposure Science . 2014

机译：成人狂热的海鲜消费群体中的汞，omega-3脂肪酸，甲状腺激素和甲状腺抗体
5. Energy intake, resting energy expenditure, activity levels, energy balance and serum hormone concentrations in sedentary and athletic males [D] . Mackenzie, Kelly Ann. 2000

机译：久坐和运动的男性的能量摄入，静息能量消耗，活动水平，能量平衡和血清激素浓度
6. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure [O] . Wagner S. da-Silva, Scott Ribich, Rafael Arrojo e Drigo, -1

机译：牛磺熊去氧和4-苯基的化学伴侣酸促进甲状腺激素活性和能量消耗
7. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure [O] . da-Silva Wagner S., Ribich Scott, Drigo Rafael Arrojo e, 2011

机译：化学伴侣牛磺去氧胆酸和4-苯基丁酸可加速甲状腺激素的活化和能量消耗

The chemical chaperones tauroursodeoxycholic and 4‐phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

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