Induction of proliferation and apoptotic cell death via P2Y and P2X receptors, respectively, in rat glomerular mesangial cells

摘要

Induction of proliferation and apoptotic cell death via P2Y and P2X receptors, respectively, in rat glomerular mesangial cells.BackgroundCell surface receptors for adenosine 5′-triphosphate (ATP; P2 receptors) have been subdivided into two families: ligand-gated ion channels (P2X1?7) and G-protein–coupled (P2Y1?8) receptors. We investigated the potential role of P2 receptors on rat glomerular mesangial cells.