Leptin stimulates type I collagen production in db/db mesangial cells: Glucose uptake and TGF-|[bgr]| type II receptor expression

摘要

Leptin stimulates type I collagen production in db/db mesangial cells: Glucose uptake and TGF- type II receptor expression.BackgroundSerum leptin levels correlate with fat cell mass and are elevated in patients with massive obesity and type 2 diabetes mellitus, which are strong risk factors for the development of glomerulosclerosis. We have previously shown in cultured glomerular endothelial cells that leptin stimulates cellular proliferation and expression of the prosclerotic cytokine transforming growth factor-1 (TGF-1). Although the effect of leptin on the hypothalamus to regulate energy homeostasis is well known, the effect of leptin on the kidney, and specifically on the glomerular mesangial cell, is unclear.