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Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney

机译:成纤维细胞生长因子和成纤维细胞生长因子受体在发育中的大鼠肾脏中的表达和定位

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Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney.BackgroundThe permanent kidney, or metanephros, develops through a complex series of reciprocal inductive events and involves branching morphogenesis, tubulogenesis, angiogenesis, and tissue remodeling. Fibroblast growth factors (FGFs) are a family of growth and differentiation factors that have been implicated in metanephric development. FGFs exert their actions through tyrosine kinase receptors, FGFRs, which are encoded by four FGFR genes (FGFR1 through FGFR4).
机译:成纤维细胞生长因子和成纤维细胞生长因子受体在发育中的大鼠肾脏中的表达和定位背景永久性肾脏或后肾通过一系列复杂的相互诱导事件发展,涉及分支形态发生,肾小管生成,血管生成和组织重塑。成纤维细胞生长因子(FGFs)是一类生长和分化因子,已与后肾发育有关。 FGF通过酪氨酸激酶受体FGFR发挥作用,该受体由四个FGFR基因(FGFR1至FGFR4)编码。

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