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首页> 外文期刊>Molecules >Comparative Studies on Phenolic Composition, Antioxidant, Wound Healing and Cytotoxic Activities of Selected Achillea L. Species Growing in Turkey
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Comparative Studies on Phenolic Composition, Antioxidant, Wound Healing and Cytotoxic Activities of Selected Achillea L. Species Growing in Turkey

机译:在土耳其生长的某些A属物种的酚类成分,抗氧化剂,伤口愈合和细胞毒性活性的比较研究

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Turkey is one of the most important centers of diversity for the genus Achillea L. in the world. Keeping in mind the immense medicinal importance of phenols, in this study, three species growing in Turkey, A. coarctata Poir. (AC), A. kotschyi Boiss. subsp. kotschyi (AK) and A. lycaonica Boiss. & Heldr. (AL) were evaluated for their phenolic compositions, total phenolic contents (TPC), antioxidant properties, wound healing potencies on NIH-3T3 fibroblasts and cytotoxic effects on MCF-7 human breast cancer cells. Comprehensive LC-MS/MS analysis revealed that AK was distinctively rich in chlorogenic acid, hyperoside, apigenin, hesperidin, rutin, kaempferol and luteolin (2890.6, 987.3, 797.0, 422.5, 188.1, 159.4 and 121.2 µg analyte/g extract, respectively). The findings exhibited a strong correlation between TPC and both free radical scavenging activity and total antioxidant capacity (TAC). Among studied species, the highest TPC (148.00 mg GAE/g extract) and TAC (2.080 UAE), the strongest radical scavenging (EC50 = 32.63 μg/mL), the most prominent wound healing and most abundant cytotoxic activities were observed with AK. The results suggested that AK is a valuable source of flavonoids and chlorogenic acid with important antioxidant, wound healing and cytotoxic activities. These findings warrant further studies to assess the potential of AK as a bioactive source that could be exploited in pharmaceutical, cosmetics and food industries.
机译:土耳其是世界上Achillea属最重要的多样性中心之一。请记住,在这项研究中,苯酚的巨大药用重要性是在土耳其生长的三个物种,即A. coarctata Poir。 (AC),A。kotschyi Boiss。亚种kotschyi(AK)和A. lycaonica Boiss。 &Heldr。评估(AL)的酚组成,总酚含量(TPC),抗氧化剂特性,对NIH-3T3成纤维细胞的伤口愈合能力以及对MCF-7人乳腺癌细胞的细胞毒性作用。全面的LC-MS / MS分析表明,AK富含绿原酸,高丝皂苷,芹菜素,橙皮苷,芦丁,山奈酚和木犀草素(分别为2890.6、987.3、797.0、422.5、188.1、159.4和121.2 µg分析物/ g提取物) 。研究结果表明,TPC与自由基清除活性和总抗氧化剂能力(TAC)之间有很强的相关性。在研究的物种中,最高TPC(148.00 mg GAE / g提取物)和TAC(2.080 UAE),最强的自由基清除能力(EC 50 = 32.63μg/ mL),最突出的伤口愈合和最用AK观察到丰富的细胞毒性活性。结果表明,AK是类黄酮和绿原酸的重要来源,具有重要的抗氧化剂,伤口愈合和细胞毒性活性。这些发现值得进一步研究,以评估AK作为一种生物活性来源的潜力,可以在制药,化妆品和食品工业中加以利用。

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