Norepinephrine-induced acute renal failure: A reversible ischemic model of acute renal failure

摘要

Several studies have shown that acute renal failure (ARF) can be produced in the dog by infusing norepinephrine (NE) into a renal artery [1, 2]. In these studies the injury appeared to be confined to the infused kidney, with no changes occurring in systemic hemodynamics or in the function of the contralateral kidney. The hemodynamic changes noted in the infused kidney were comparable to those seen in human ARF. A major criticism of these studies, however, is that the renal failure was not shown to be reversible, as it typically is in man. In the present study, we have reexamined the NE-induced model of ARF in the dog with the particular purpose of finding a set condition which would cause ARF and yet allow recovery of renal function within a period of time comparable to that usually seen in the human disease.