Response to Detection of New Delhi Metallo-β-Lactamase–Producing Bacteria, Brazil

摘要

To the Editor: New Delhi metallo-β-lactamase (NDM) is an example of a successful antimicrobial drug resistance determinant and has become one of the most clinically significant carbapenemases. The gene bla NDM was first described in India in 2009. Its dispersion is epide- miologically linked to the Indian subcontinent, from which increased international transmission has been detected in nosocomial, community, and environmental isolates (1). Currently, the main acquired carbapenemases around the world are Klebsiella pneumoniae carbapenemase (KPC), oxacillinase-48 (OXA-48), and NDM. KPC is broadly detected and endemic to some areas; OXA-48 has been widely disseminated throughout European countries and has been reported in other regions. NDM is reported almost worldwide but did not successfully spread in most coun - tries of Europe except the United Kingdom and recently, France, as has been found in Enterobacteriaceae (2) and in nonfermenting gram-negative bacilli, with progression toward rapid global prevalence.