Reservoir Host Expansion of Hantavirus, China (http://wwwnc.cdc.gov/eid/article/21/1/14-0960)

摘要

To the Editor: Hemorrhagic fever with renal syndrome (HFRS) is caused by hantavirus. During 1995–2005, China reported 20,000–50,000 cases of HFRS annually, which represents 90% of HFRS cases worldwide ( 1 – 3 ). In China, HFRS is caused mainly by 2 serotypes of hantavirus: Hantaan virus (HTNV) and Seoul virus (SEOV) ( 4 ). Pathogenic hantavirus serotypes are considered to be strictly associated with their serotype-specific reservoir hosts. HTNV is associated with the striped field mouse ( Apodemus agrarius ), and SEOV is associated with the brown rat ( Rattus norvegicus ) and the black rat ( Rattus rattus ) ( 4 , 5 ). HTNV causes a severe form of HFRS, characterized by renal failure that in some cases is followed by pulmonary edema and disseminated intravascular coagulation; the estimated death rate is 5%–15%. SEOV causes a moderate form of HFRS ( 6 ).