Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses (http://wwwnc.cdc.gov/eid/article/21/2/14-1649)

摘要

We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.