Antimicrobial-Drug Use and Methicillin-Resistant Staphylococcus aureus

摘要

To the Editor: We read with great interest the debate on the contribution of antimicrobial selection pressure to changes in resistance in Salmonella enterica serovar Typhimurium and the comparison made with methicillin-resistant Staphylococcus aureus (MRSA) (1). We strongly agree with Davis et al. that infection control practices must play a central role in successful MRSA control programs. However, we disagree that the antimicrobialdrug use practices that contribute to the control of MRSA have not been scientifically defined. In a recent review, we identified more than 20 studies on consistent associations, dose-effect relationships, and concomitant variations, all supporting a causal relationship between antimicrobial-drug use and MRSA (2).