Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004

摘要

The food supply, including poultry products, may trans-mit antimicrobial drug–resistant Escherichia colito humans. To assess this hypothesis, 931 geographically and tempo-rally matched E. coliisolates from human volunteers (hos-pital inpatients and healthy vegetarians) and commercial poultry products (conventionally raised or raised without antimicrobial drugs) were tested by PCR for phylogenetic group (A, B1, B2, D) and 60 virulence genes associated with extraintestinal pathogenic E. coli. Isolates resistant to trimethoprim-sulfamethoxazole, quinolones, and extended-spectrum cephalosporins (n = 331) were compared with drug-susceptible isolates (n = 600) stratifi ed by source. Phylogenetic and virulence markers of drug-susceptible human isolates differed considerably from those of human and poultry isolates. In contrast, drug-resistant human iso-lates were similar to poultry isolates, and drug-susceptible and drug-resistant poultry isolates were largely indistin-guishable. Many drug-resistant human fecal E. coliisolates may originate from poultry, whereas drug-resistant poultry-source E. coliisolates likely originate from susceptible poul-try-source precursors