Unusual Manifestation of Toscana Virus Infection, Spain

摘要

To the Editor: Toscana virus (TOSV) causes acute meningitis and meningoencephalitis in Mediterranean countries (1). In Spain, neurologic TOSV infection has been reported since 1988. All cases have been selflimited aseptic meningitis (2). Since 2003, we have routinely investigated TOSV in cerebrospinal fl uid (CSF) specimens from patients with suspected viral meningitis and encephalitis by using cell culture and reverse transcription– PCR (RT-PCR) (3,4). Also, as part of a regional project (05/305, Consejería de Salud, Junta de Andalucía, Spain), we investigated TOSV in mild nonneurologic syndromes by detection of immunoglobulin (Ig) M against TOSV by using enzyme immunoassay (Diesse Diagnostica Senese S.p.A, Siena, Italy). From May through September of 2006 and 2007, a total of 358 serum samples were randomly selected from patients for whom microbiologic determinations had been requested to investigate febrile illnesses.