Polymyxin B Resistance in Carbapenem-Resistant Klebsiella pneumoniae , S?o Paulo, Brazil

摘要

To the Editor: Infections caused by carbapenem-resistant Enterobacteriaceae have been associated with higher death rates than infections caused by carbapenem-susceptible strains, and resistant infections are mostly treated with polymyxins (1). Several outbreaks caused by carbapenem- and polymyxin-resistant Klebsiella pneumoniae (CPRKp) have been reported, mainly from Europe, and represent an emerging threat.Carbapenem-resistant K. pneumoniae (CRKp) are endemic to Brazil, where polymyxin B (PMB) has been largely used against infections caused by these microorganisms. We evaluated PMB resistance rates and clonal diversity among CRKp isolates from patients in S?o Paulo, Brazil. The study was approved by the Research Review Board of Fleury Institute in S?o Paulo.