Decreasing Shigellosis-related Deaths without Shigella spp.–specific Interventions, Asia

摘要

In 1999, a review of the literature for 1966–1997 sug-gested that ≈ 1.1 million persons die annually of shigellosis, including ≈ 880,000 in Asia. Our recent review of the litera-ture for 1990–2009 indicates that ≈125 million shigellosis cases occur annually in Asia, of which ≈14,000 are fatal. This estimate for illnesses is similar to the earlier estimate, but the number of deaths is 98% lower; that is, the lower es-timate of deaths is associated with markedly reduced case-fatality rates rather than fewer cases. Shigella spp.–related deaths decreased substantially during a period without Shi-gella spp.–specifi c interventions. We speculate that non-specifi c interventions, e.g., measles vaccination, vitamin A supplementation, and improved nutrition, may have led to the reduced number of shigellosis-related deaths