Choroidal Thickness In Glaucoma Patients And Glaucoma Suspects Measured By Spectral Domain Coherence Optical Tomography

摘要

Purpose: : The aim of our study was to evaluate and compare retro-foveolar choroidal thickness (RFCT) of healthy subjects, individuals with intraocular hypertension, patients with primary open-angle glaucoma (POAG), patients with normal tension glaucoma (NTG) and patients with primary angle-closure glaucoma (PACG) by spectral domain optical coherence tomography (SD-OCT). Methods: : Sixty-five healthy eyes, 30 eyes with intraocular hypertension, 90 eyes with POAG, 30 eyes with NTG and 20 eyes with PACG were included in this cross-sectional study. RFCT, foveolar retinal thickness and average retinal nerve fiber layer thickness (RNFL) were measured by SD-OCT (Spectralis HRA-OCT, Heidelberg Engineering). Choroidal area was measured centered on the fovea, extending 2500 ??m in temporal and nasal directions with Image J software. Parapapillary atrophy (PPA) was noted with optic nerve digital stereophotography. Humphrey 24-2 visual field was also performed and spherical equivalent (SE) was measured with an automatic refractometer. Results: : In univariate analysis, significant correlations were observed between RFCT and age, choroidal area, PPA (p0.001), SE, intraocular pressure, topical prostaglandin analogs (p0.030), POAG, PACG (p0.001) and NTG (p=0.006). In multivariate analysis, RFCT was correlated with age, choroidal area, PPA and PACG (p0.001). Average RFCT was statistically thicker in PACG patients compared to healthy subjects (341 ?± 95 ??m versus 235 ?± 56 ??m, p0.001). Conclusions: : This preliminary study showed that RFCT measured by SD-OCT was significantly thicker in PACG compared to healthy subjects.