Control of Nucleotide Metabolism Enables Mutant p53?￠????s Oncogenic Gain-of-Function Activity

摘要

Since its discovery as an oncoprotein in 1979, investigation into p53?￠????s many identities has completed a full circle and today it is inarguably the most extensively studied tumor suppressor (wild-type p53 form or WTp53) and oncogene (mutant p53 form or mtp53) in cancer research. After the p53 protein was declared ?￠????Molecule of the Year?￠???? by Science in 1993, the p53 field exploded and a plethora of excellent reviews is now available on every aspect of p53 genetics and functional repertoire in a cell. Nevertheless, new functions of p53 continue to emerge. Here, we discuss a novel mechanism that contributes to mtp53?￠????s Gain of Functions GOF (gain-of-function) activities and involves the upregulation of both nucleotide de novo synthesis and nucleoside salvage pathways.