Tetracyclines modulate cytokine production and induce autophagy in THP-1 cells

摘要

Purpose: We previously reported that excess production of cytokine is associated with the increase in severity in rickettsial infection. Recently some researcher reported that autophagy has the pivotal role for biological defense mechanism in various infections. However, few reports are found which clarified that rickettsial infection induced autophagy. Tetracycline (TC) is the first line of treatment in rickettsial infection. This study elucidated that minocycline (MINO) and tigecycline (TGC) suppress cytokine production and induce autophagy in addition to acting as antibiotics.