An oral formulation of Amphotericin B for the treatment of visceral Leishmaniasis: f-Gr-AmB

摘要

Background: The oral administration of Amphotericin B (AmB) has a major drawback of poor gastrointestinal solubility and permeability. The aim of this study was to investigate the potential of functionalized graphene as a nanocarrier to improve the oral efficacy of AmB. Antileishmanial activity was determined in vivo in hamsters to investigate its therapeutic use.