Viruses in CSF of HIV patients with acute and late onset neurological conditions detected by NGS

摘要

Background: Neurological symptoms are common in HIV-infected patients, with meningitis, stroke and seizures associated with acute onset conditions and neurocognitive disorders (HAND) common in late infection. Identifying a specific cause is difficult, with potential infectious aetiologies limited by the diagnostic repertoire available in the routine microbiology and virology laboratory. Next generation sequencing (NGS) is an unbiased approach to search for novel and other neurotropic infectious agents.