Economic assessment of implementing Hexaxim(R) vaccine within the South African Expanded Programme on Immunisation (EPI-SA)

摘要

Background: The South African Expanded Programme on Immunisation (EPI-SA) currently vaccinates against 10 childhood vaccine preventable diseases. Six injections are required for primary vaccination against diphtheria, tetanus, pertussis, polio, Haemophilus influenza type b and hepatitis B: three DTaP-IPV//Hib [Pentaxim?] doses and three monovalent Hep B vaccines to children under 12 months of age, with a seventh injection (Pentaxim? booster) at 18 months. Madhi et al (PIDJ 30:e68 2011) demonstrated no significant difference in the safety and efficacy between Pentaxim? plus monovalent Hep B and a new fully liquid hexavalent vaccine, Hexaxim? (DTaP-IPV-Hib-HepB).