Pneumococcal conjugate vaccine (non-typeable Haemophilus influenzae (NTHi) Protein D, diphtheria or tetanus toxoid conjugates) in prevention of acute otitis media in children: A cohort study

摘要

Background: Acute otitis media (AOM) is a common diagnosis among children. The most common causative bacteria in AOM are Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. In March 2009, a pneumococcal vaccine containing ten serotype-specific polysaccharides conjugated to Haemophilus influenzae protein D, tetanus toxoid, and diphtheria toxoid as the carrier proteins was developed and licensed.