NRTI resistance profile of the subtype F HIV-1 strains from children and adolescents treated with multiple antiretroviral drugs

摘要

Background: The HIV epidemic in Romania is characterized by the existence of a large cohort of children and adolescents that have been infected in the late eighties. Most of these patients have been under treatment for the last ten years: all of them are currently on HAART but their majority has experienced a period (years) of either monotherapy (AZT) or bitherapy (AZT with 3TC or ddC). This study examines resistance profiles in the RT gene of HIV-1 strains obtained from these patients.