vax-SPIRAL(R): Cuban antileptospirosis vaccines for humans: Clinical and field assays and impact of the vaccine on the disease after 11 years of application in Cuba

摘要

Background: In Cuba, leptospirosis has shown an endemoepidemic behavior, with an important increase in morbility between 1991 and 1995, that is why these years have been considered epidemic. According to what had been foreseen within the Leptospirosis Prevention and Control Program, a Russian vaccine was administered to persons at risk of getting the disease since 1983. In 1991, import of this vaccine was stopped and, in order to find an alternative solution to this health problem, it was decided to start the development of a trivalent Cuban vaccine with autochthonous strains (Icteroahemorrahgiae, Canicola, Pomona).