Role of Efflux pumps in the development of quinolone-resistance in Peruvian Escherichia coli isolates

摘要

Background: Active efflux pumps are important in the development of antibiotic-resistance. Inhibitor efflux pumps are under investigation because the possibility to be used in the future together with antimicrobial agents. Phe-Arg-$- naphthylamide (PAN) is a broad spectrumefflux pump inhibitor on quinolone susceptibilities in microorganisms such as Escherichia coli. The objective of this study is to determine the effect of PAN in the MIC of quinolones, to relate its effect with the presence of mutations in gyrA and parC genes and with the presence of transferable mechanisms of quinolone-resistance (qnr and aac(6’)Ib-cr genes) in Escherichia coli peruvian isolates.