Association of tumor necrosis factor-alpha gene promoter regions polymorphism in Japanese encephalitis patients

摘要

Background: More than three billion populations are living under the threat of Japanese encephalitis in the south East Asian countries including India. The pathogenesis of this disease is not clearly understood, and is possibly attributed to the genomic variation in virus as well the host genetic make up. The present study focused to determine the role of -238G/A, -857C/T and -863C/A polymorphism of tumor necrosis factor-alpha (TNF-a), gene promoter polymorphism in Japanese encephalitis patients as a part of host role in disease severity and pathogenesis.