The Role of Dengue NS1, Through the Modulation of STAT3 Signaling, in the Pathogenesis of Dengue Virus Infection

摘要

Background: In an earlier study, NS1 was also shown to be able to interact with STAT3 β, an acute-phase protein and NS1 over-expression in dendritic cells results in increased production of pro-inflammatory cytokines. These results points towards a role played by NS1 in the pathogenesis of dengue virus infection. Hence, this study aims to further our current understanding of this role played by NS1, in particular, its effects on STAT3 signaling.