early detection method and early diagnosis kit of a flaviviral infection, process of purification of a flavivirus ns1 protein, immunogenic composition, use of ns1 protein, at least one anti-ns1 monoclonal antibody and ns1 protein hexamerically, and , expression process of a polynucleotide encoded for dengue virus ns1 protein

摘要

"early detection method of a flaviviral infection, early diagnosis kit, process of purification of a flavivirus ns1 protein, immunogenic composition, use of ns1 protein, at least one anti-ns1 monoclonal antibody, and process of expression of a polynucleotide encoding dengue virus ns1 protein ". An early method for detecting a flaviviral infection comprising detecting the non-structural flavivirus glycoprotein ns1 in a biological sample during the clinical phase of the infection by an immunological method employing at least two identical or different antibodies, the first antibody comprising polyclonal or monoclonal antibodies previously selected for their high affinity for said hexameric ns1 protein.