An AUC Based Method for Aminoglycoside Dosing Adjusting for Drug Excretion During Infusion and Allowing Early Recognition of Drug Accumulation

摘要

Background: Once daily aminoglycoside dosing is now standard. Area Under the curve (AUC) is the best predictor of bacterial killing and toxicity. Formulas or applications based on two concentration measurements are widely used to optimise the AUC. Published methods do not account for excretion during the infusion which varies greatly with infusion duration. Drug accumulation may not be apparent from the AUC calculated after an initial inappropriately small dose. Formulas simple enough to be put on any spreadsheet application or handheld device were developed to deal with these problems.