Efficacy of Intravenous Paracetamol Infusion for Attenuation of Hemodynamic Responses to Laryngoscopy and Tracheal Intubation

摘要

Background and Aim: Pressor response in relation to laryngoscope and tracheal intubation generally lead to rise in heart rate and blood pressure. This response needs to be controlled. The aim is to study efficacy of intravenous paracetamol infusion given before induction to control hemodynamic response at laryngoscopy and endotracheal intubation. Materials and Methods: It was prospective randomized study, after institution ethical committee clearance, Sixty patients of American society of Anaesthesiology class I and II undergoing elective surgery under general anaesthesia were selected and divided into two groups each comprising 30 patients.Group P received inj. Paracetamol -20mg/kg 30 min before induction and Group F received inj. Fentanyl 1mcg/kg before induction. The primary objective was to observe hemodynamic response at intubation and 1,3,5,10 min after intubation. The secondary objective was to measure rate pressure product and any side effects associated with drug. Results: There was no demographic difference found between two groups. Both the group showed decreased hemodynamic response, but it was highly significant with inj.fentanyl. Conclusion: IV Paracetamol administration 30 minutes before induction does attenuate hemodynamic response but not as significant as with inj. Fentanyl.