Microbial Transformation of 19-Hydroxypregnanes

摘要

Nocardia species aromatized 19-hydroxyprogesterone, 3β, 19-dihydroxy-pregn-5-en-20-one 3-acetate and pregn-5-ene-3β, 19, 20β-triol 3-acetate, without cleavage of the side chain, into 3-hydroxy-19-norpregna-1,3,5 (10)-trien-20-one. Septomyxa affinis aromatized the ring A and cleaved the side chain of 19-hydroxyprogesterone to yield estrone. With 19-hydroxypregna-4, 7-diene-3, 20-dione as substrate, the transformation was more complex and many products were formed.