Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic|[ndash]|pharmacodynamic analysis from the IELSG no. 20 trial

M Joerger; A D R Huitema; S Kr?henbühl; J H M Schellens; T Cerny; M Reni; E Zucca; F Cavalli; A J M Ferreri

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Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic|[ndash]|pharmacodynamic analysis from the IELSG no. 20 trial

机译：曲线下的甲氨蝶呤面积是原发性中枢神经系统淋巴瘤患者重要的预后指标：来自IELSG no.1的药代动力学分析。 20次试用

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Background:This analysis was initiated to define the predictive value of the area under the curve of high-dose methotrexate (AUCHD-MTX) in patients with primary central nervous system lymphoma (PCNSL).

机译：背景：这项分析旨在确定大剂量甲氨蝶呤（AUCHD-MTX）曲线下面积对原发性中枢神经系统淋巴瘤（PCNSL）患者的预测价值。

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《British Journal of Cancer 》 |2010年第4期| 共5页
作者
M Joerger; A D R Huitema; S Kr?henbühl; J H M Schellens; T Cerny; M Reni; E Zucca; F Cavalli; A J M Ferreri;
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中图分类肿瘤学 ;
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1. Effects on Survival and Neurocognitive Functions of Whole-Brain Radiotherapy (WBRT) and Autologous Stem Cell Transplantation (ASCT) as Consolidation Options after High-Dose Methotrexate-Based Chemoimmunotherapy in Patients with Newly Diagnosed Primary CNS Lymphoma (PCNSL): Results of the Second Randomization of the IELSG32 Trial [J] . Ferreri Andres J. M., Cwynarski Kate, Pulczynski Elisa Jacobsen, Blood: The Journal of the American Society of Hematology . 2016 ,第22期

机译：对全脑放射疗法（WBRT）和自体干细胞移植（ASCT）的生存和神经认知功能对新诊断的原发性CNS淋巴瘤（PCNSL）的高剂量甲氨蝶呤疗效后的固结选择作为合并选择：第二种随机化的结果 IELSG32试验
2. High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial. [J] . Ferreri AJ, Reni M, Foppoli M The Lancet . 2009 ,第9700期

机译：原发性中枢神经系统淋巴瘤患者的大剂量阿糖胞苷加大剂量甲氨蝶呤与单独使用大剂量甲氨蝶呤：一项随机的2期临床试验。
3. Area under the curve of methotrexate and creatinine clearance are outcome-determining factors in primary CNS lymphomas [J] . A J M Ferreri, E Guerra, M Regazzi, British Journal of Cancer . 2004 ,第2期

机译：甲氨蝶呤曲线下面积和肌酐清除率是原发性中枢神经系统淋巴瘤的决定因素
4. Predicting lymphoma outcomes and risk factors in patients with primary Sjögren’s Syndrome using gradient boosting tree ensembles [C] . Vasileios C. Pezoulas, Themis P. Exarchos, Athanasios G. Tzioufas, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：使用梯度增强树组合预测原发性干燥综合征患者的淋巴瘤结局和危险因素
5. Propafenone pharmacokinetics: GLC-ECD analysis; metabolic induction by phenobarbital in nonsmoking and smoking healthy volunteers; protein binding; pharmacodynamics in patients [D] . Chan, Grace Lap-Yu 1989

机译：普罗帕酮药代动力学：GLC-ECD分析；非吸烟和吸烟健康志愿者的苯巴比妥诱导代谢；蛋白质结合；患者的药效学
6. Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic–pharmacodynamic analysis from the IELSG no. 20 trial [O] . M Joerger, A D R Huitema, S Krähenbühl, 2010

机译：曲线下的甲氨蝶呤面积是原发性中枢神经系统淋巴瘤患者重要的预后指标：IELSG的药代动力学-药效学分析。 20次试用
7. Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic–pharmacodynamic analysis from the IELSG no. 20 trial [O] . Joerger, M, Huitema, A D R, Krähenbühl, S, 2010

机译：曲线下的甲氨蝶呤面积是原发性中枢神经系统淋巴瘤患者重要的预后指标：IELSG的药代动力学-药效学分析。 20次试用

Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic|[ndash]|pharmacodynamic analysis from the IELSG no. 20 trial

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