Adaptive designs for clinical trials assessing biomarker-guided treatment strategies

J Wason; A Marshall; J Dunn; R C Stein; N Stallard

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Adaptive designs for clinical trials assessing biomarker-guided treatment strategies

机译：用于评估生物标记物指导治疗策略的临床试验的自适应设计

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Background:The Biomarker Strategy Design has been proposed for trials assessing the value of a biomarker in guiding treatment in oncology. In such trials, patients are randomised to either receive the standard chemotherapy treatment or a biomarker-directed treatment arm, in which biomarker status is used to guide treatment.

机译：背景：已经提出了生物标志物策略设计，用于评估生物标志物在指导肿瘤治疗中的价值的试验。在此类试验中，患者被随机分配接受标准化学疗法治疗或以生物标志物为导向的治疗组，其中使用生物标志物状态来指导治疗。

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《British Journal of Cancer》 |2014年第8期|共8页
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J Wason; A Marshall; J Dunn; R C Stein; N Stallard;
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机译：关于验证性自适应临床试验的态度和观点：来自将有希望的试验加速应用于治疗的自适应设计（ADAPT-IT）项目的混合方法分析
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机译：Amsterdam Investigator-initiateD Absorb策略所有患者试验（AIDA试验）：一项临床评估，比较了ABSORB依维莫司洗脱生物可吸收血管支架策略与XIENCE系列（XIENCE PRIME或XIENCE Xpedition）依维莫司洗脱冠状动脉支架策略的疗效和性能连续性所有患者的冠状动脉病变的治疗：原理和研究设计
4. Assessing the population representativeness of colorectal cancer treatment clinical trials [C] . Zhe He, Zhiwei Chen, Thomas J George, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

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5. Design and Analysis of Trials for Developing Adaptive Treatment Strategies in Complex Clustered Settings [D] . Ktsanes, Rachel. 2017

机译：复杂聚类环境下制定适应性治疗策略的试验设计与分析
6. Adaptive designs for clinical trials assessing biomarker-guided treatment strategies [O] . J Wason, A Marshall, J Dunn, 2014

机译：用于评估生物标志物指导治疗策略的临床试验的自适应设计
7. Attitudes and opinions regarding confirmatory adaptive clinical trials: a mixed methods analysis from the Adaptive Designs Accelerating Promising Trials into Treatments (ADAPT-IT) project [O] . William J. Meurer, Laurie Legocki, Samkeliso Mawocha, 2016

机译：关于验证性自适应临床试验的态度和观点：来自将有希望的试验加速应用于治疗的自适应设计（ADAPT-IT）项目的混合方法分析

Adaptive designs for clinical trials assessing biomarker-guided treatment strategies

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