Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity

M J M Gooden; V R Wiersma; A Boerma; N Leffers; H M Boezen; K A ten Hoor; H Hollema; A M E Walenkamp; T Daemen; H W Nijman; E Bremer

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Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity

机译：血清CXCL16升高是卵巢癌存活率低的独立预测因子，可能反映了转移前ADAM蛋白酶的活性

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Background:In certain cancers, expression of CXCL16 and its receptor CXCR6 associate with lymphocyte infiltration, possibly aiding anti-tumour immune response. In other cancers, CXCL16 and CXCR6 associate with pro-metastatic activity. In the current study, we aimed to characterise the role of CXCL16, sCXCL16, and CXCR6 in ovarian cancer (OC).

机译：背景：在某些癌症中，CXCL16及其受体CXCR6的表达与淋巴细胞浸润相关，可能有助于抗肿瘤免疫反应。在其他癌症中，CXCL16和CXCR6与转移活性有关。在当前的研究中，我们旨在表征CXCL16，sCXCL16和CXCR6在卵巢癌（OC）中的作用。

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《British Journal of Cancer》 |2014年第6期|共10页
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M J M Gooden; V R Wiersma; A Boerma; N Leffers; H M Boezen; K A ten Hoor; H Hollema; A M E Walenkamp; T Daemen; H W Nijman; E Bremer;
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中图分类肿瘤学;
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入库时间 2022-08-18 17:48:02

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6. Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity [O] . M J M Gooden, V R Wiersma, A Boerma, 2014

机译：血清CXCL16升高是卵巢癌存活率低的独立预测因子可能反映了转移前ADAM蛋白酶的活性
7. Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity [O] . Gooden, M. J. M., Wiersma, V. R., Boerma, A., 2014

机译：血清CXCL16升高是卵巢癌存活率低的独立预测因子，可能反映了转移前ADAM蛋白酶的活性

Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity

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