Reproductive risk factors and oestrogen|[sol]|progesterone receptor-negative breast cancer in the Breast Cancer Family Registry

摘要

Background:Oestrogen receptor (ER)- and progesterone receptor (PR)-negative (ER?PR?) breast cancer is associated with poorer prognosis compared with other breast cancer subtypes. High parity has been associated with an increased risk of ER?PR? cancer, but emerging evidence suggests that breastfeeding may reduce this risk. Whether this potential breastfeeding benefit extends to women at high risk of breast cancer remains critical to understand for prevention.