Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer

L Chen; L Fu; X Kong; J Xu; Z Wang; X Ma; Y Akiyama; Y Chen; J Fang

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Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer

机译：含有Jumonji域的蛋白2B沉默通过STAT3途径诱导大肠癌DNA损伤反应

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Background:Jumonji domain-containing protein 2B (JMJD2B), directly targeted by hypoxia-inducible factor 1α, maintains the histone methylation balance important for the transcriptional activation of many oncogenes. Jumonji domain-containing protein 2B has been implicated in colorectal cancer (CRC) progression; however, the mechanism remains unclear.

机译：背景：含Jumonji域的蛋白2B（JMJD2B）被缺氧诱导因子1α直接靶向，维持了组蛋白甲基化平衡，这对于许多癌基因的转录激活至关重要。含有Jumonji结构域的蛋白2B与结直肠癌（CRC）的进展有关。但是，机制尚不清楚。

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《British Journal of Cancer》 |2014年第4期|共13页
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L Chen; L Fu; X Kong; J Xu; Z Wang; X Ma; Y Akiyama; Y Chen; J Fang;
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中图分类肿瘤学;
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1. MiR-873-5p suppresses cell proliferation and epithelial-mesenchymal transition via directly targeting Jumonji domain-containing protein 8 through the NF-kappa B pathway in colorectal cancer [J] . Wang Liqiang, Jiang Fuquan, Ma Feng, Journal of Cell Communication and Signaling . 2019,第4期

机译：MiR-873-5P通过直接靶向含Jumonji域域的蛋白质8，通过直肠癌的NF-Kappa B途径直接靶向细胞增殖和上皮 - 间充质转化
2. MiR-873-5p suppresses cell proliferation and epithelial mesenchymal transition via directly targeting Jumonji domain-containing protein 8 through the NF-B pathway in colorectal cancer [J] . Liqiang Wang, Fuquan Jiang, Feng Ma, Journal of Cell Communication and Signaling . 2019,第4期

机译：miR-873-5p通过直接靶向含Jumonji结构域的蛋白质8，通过直肠癌中的NF-B途径直接靶向细胞增殖和上皮间充质过渡
3. Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-x L and BID Protein Expression by Modulating Signaling Proteins Erk 1/2 and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines [J] . Abdulrahman Khazim Al-Asmari, Anvarbatcha Riyasdeen, Mozaffarul Islam Integrative cancer therapies. . 2018,第2期

机译：通过调节信号蛋白ERK 1/2和STAT3和DNA损伤，蝎子毒液引起P53和BCL-X L和BID蛋白表达的下调和BID蛋白表达的下调，以及乳腺癌和结肠直肠癌细胞系中的DNA损伤
4. Over-activation of the stat3 pathway in lung epithelial cells induces pulmonary inflammation and lung cancer [C] . Liu Yujie, rnPiao Linhua, rnSong Jia, Journal of Organ Dysfunction: ISRD 2007 Abstract Book . 2007

机译：肺上皮细胞中stat3通路的过度激活引起肺部炎症和肺癌
5. Novel role of heat shock protein (HSP) 90 in regulating ATR-CHK1 DNA damage response pathway in cancer cells. [D] . Ha, Kyungsoo. 2011

机译：热休克蛋白（HSP）90在调节癌细胞中ATR-CHK1 DNA损伤反应途径中的新作用。
6. Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer [O] . L Chen, L Fu, X Kong, 2014

机译：含有Jumonji域的蛋白2B沉默通过STAT3途径诱导结直肠癌的DNA损伤反应
7. MiR-873-5p suppresses cell proliferation and epithelial–mesenchymal transition via directly targeting Jumonji domain-containing protein 8 through the NF-κB pathway in colorectal cancer [O] . Liqiang Wang, Fuquan Jiang, Feng Ma, 2019

机译：miR-873-5p通过直接靶向含Jumonji结构域的蛋白质8，通过直肠癌中的NF-κB途径直接靶向细胞增殖和上皮 - 间充质转化

Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer

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